OBSERVATIONS ON DIPHTHERIA TOXOID AS AN IMMUNIZING AGENT
نویسندگان
چکیده
منابع مشابه
On the antigenicity of diphtheria toxoid. IV. The usefulness of the quantitative Schick test as the response in the assay of immunizing potency.
Several diphtheria toxoid preparations were fractionated by salting out with ammonium sulphate at various concentrations into several fractions possessing evidently different immunizing potency. The fractions of lower solubility were proved to possess less potency than those of higher solubility when the comparison was performed at the same Lf dose6). This difference between the potency of thes...
متن کاملThe Purification and Concentration of Diphtheria Toxoid
By precipitation with acetone at 4 degrees C. a refined diphtheria toxoid was obtained as a dry powder, readily soluble in aqueous solutions. The powder itself appears to be stable. When dissolved in half the original volume of physiological salt solution, the toxoid remained stable, in the cold room, for a period of 7 months. Only toxoids should be used which have been completely detoxified by...
متن کاملThe Relation of Toxoid Dilution to Immunizing Capacity *
Thus far most of those procedures adopted for the production of antibody have been of an arbitrary nature with attention chiefly directed toward the quality and quantity of the antigen and the parenteral route of its introduction. It is, however, becoming more and more clear that the factors which govern the extent to which an animal of a given species will respond with elaboration of antibody ...
متن کاملPreparation and in-vitro evaluation of sodium alginate microspheres containing diphtheria toxoid as new vaccine delivery
During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...
متن کاملPreparation and Evaluation of Diphtheria Toxoid-Containing Microspheres
Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT. In the first step, following the purification of semi-crude DT by the ion-exchan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Public Health
سال: 1924
ISSN: 0271-4353
DOI: 10.2105/ajph.14.12.1047